Name: A 78773
Rating: 5 (10 reviews)

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HIT ID:HIT212711897
Cas No:141579-67-1
常用名:A 78773
别名:A-78773, A78773
IUPAC:1-{4-[5-(4-fluorophenoxy)furan-2-yl]but-3-yn-2-yl}-1-hydroxyurea
IUPAC:1-{4-[5-(4-fluorophenoxy)furan-2-yl]but-3-yn-2-yl}-1-hydroxyurea
InChI key:OLZHFFKRBCZHHT-UHFFFAOYSA-N

分子式:C15H13FN2O4
分子量:304.277
氢键供体数 (HBD):2
氢键受体数 (HBA):2
LogP:2.2640793
SMILES:CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
SMILES:CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O

A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflammation and allergy, edema, inflammatory cell influx, and bronchospasm. It may treat asthma and inflammatory bowel disease.

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