Name: A 80b
Rating: 5 (10 reviews)

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HIT ID:HIT212711902
Cas No:135561-94-3
常用名:A 80b
别名:A-80b, A80b
IUPAC:3,5-dimethyl-1-[(1E)-1-(2-methylhydrazin-1-ylidene)-1H,2H,5H-pyridazino[4,5-b]indol-4-yl]-1H-pyrazole
IUPAC:3,5-dimethyl-1-[(1E)-1-(2-methylhydrazin-1-ylidene)-1H,2H,5H-pyridazino[4,5-b]indol-4-yl]-1H-pyrazole
InChI key:LZAUTKZCXBBSMB-UHFFFAOYSA-N

分子式:C16H17N7
分子量:307.361
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:1.224644
SMILES:CN\N=c1\[nH]nc(-n2nc(C)cc2C)c2[nH]c3ccccc3c12
SMILES:CN\N=c1\[nH]nc(-n2nc(C)cc2C)c2[nH]c3ccccc3c12

A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. Hypotensive and antihypertensive effect of A-80b possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.

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