Name: AZD-9164 bromide
Rating: 5 (10 reviews)

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HIT ID:HIT212712157
Cas No:1034916-72-7
常用名:AZD-9164 bromide
别名:AZD-9164, AZD9164, AZD 9164
IUPAC:(3R)-1-[2-(4-fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(piperidin-1-yl)propanoyl]oxy}-1-azabicyclo[2.2.2]octan-1-ium bromide
IUPAC:(3R)-1-[2-(4-fluorophenyl)ethyl]-3-{[(2S)-2-phenyl-2-(piperidin-1-yl)propanoyl]oxy}-1-azabicyclo[2.2.2]octan-1-ium bromide
InChI key:QMMVAOGTOFQHAQ-BBCWMUSQSA-M

分子式:C29H38BrFN2O2
分子量:545.537
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:1.4027569
SMILES:[Br-].C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCc3ccc(F)cc3)CCC1CC2)c1ccccc1
SMILES:[Br-].C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCc3ccc(F)cc3)CCC1CC2)c1ccccc1

AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice.

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