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  3. HIT212712184
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HIT212712184
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HIT212712184
  • HIT ID:HIT212712184
  • Cas No:118587-22-7
  • 常用名:BBR 2160
  • 别名:BBR-2160, BBR2160
  • IUPAC:3-ethyl 5-methyl 2-{[(2-formamidoethyl)sulfanyl]methyl}-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
    IUPAC:3-ethyl 5-methyl 2-{[(2-formamidoethyl)sulfanyl]methyl}-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • InChI key:CLMNTOZRDYXVRT-UHFFFAOYSA-N
  • 分子式:C21H25N3O7S
  • 分子量:463.51
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):6
  • LogP:1.3213421
  • SMILES:CCOC(=O)C1=C(CSCCNC=O)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,16|
    SMILES:CCOC(=O)C1=C(CSCCNC=O)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,16|
  • BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties of BBR 2160 on guinea-pig papillary muscle and sheep Purkinje fibres. BBR 2160 (10(-7) and 10(-6) M) dose dependently decreased the contractility of driven papillary muscle and Purkinje fibre. This effect was associated with a lowering of the plateau phase and a shortening of action potential duration in papillary muscle.
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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