Name: Bepafant
Rating: 5 (10 reviews)

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sdf 文件

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类似物检索

HIT ID:HIT212712207
Cas No:114776-28-2
常用名:Bepafant
别名:WEB-2170, WEB2170, WEB 2170, STY-2108, STY 2108
别名:WEB-2170, WEB2170, WEB 2170, STY-2108, STY 2108
IUPAC:9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene
IUPAC:9-(2-chlorophenyl)-3-methyl-13-(morpholine-4-carbonyl)-16-thia-2,4,5,8-tetraazatetracyclo[8.6.0.0^{2,6}.0^{11,15}]hexadeca-1(10),3,5,8,11(15)-pentaene
InChI key:FWYVRZOREBYLCY-UHFFFAOYSA-N

分子式:C23H22ClN5O2S
分子量:467.97
氢键供体数 (HBD):0
氢键受体数 (HBA):5
LogP:2.7543688
SMILES:Cc1nnc2CN=C(c3c4CC(Cc4sc3-n12)C(=O)N1CCOCC1)c1ccccc1Cl |c:6|
SMILES:Cc1nnc2CN=C(c3c4CC(Cc4sc3-n12)C(=O)N1CCOCC1)c1ccccc1Cl |c:6|

Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was absent.

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