Name: BMS-902483
Rating: 5 (10 reviews)

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HIT ID:HIT212712289
Cas No:1192810-88-0
常用名:BMS-902483
IUPAC:(1s,2R,4R)-N-(isoquinolin-3-yl)-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxazol]-5'-amine
IUPAC:(1s,2R,4R)-N-(isoquinolin-3-yl)-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxazol]-5'-amine
InChI key:ZDTPXUKLGIDOCS-SFHVURJKSA-N

分子式:C18H20N4O
分子量:308.385
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:2.5276728
SMILES:C1N=C(Nc2cc3ccccc3cn2)O[C@]11C[N@@]2CC[C@H]1CC2 |wD:15.16,17.26,20.24,t:1,(4.2,-.14,;5.69,.25,;5.78,1.79,;7.08,2.62,;7,4.16,;8.3,4.99,;8.22,6.53,;9.52,7.37,;9.44,8.9,;8.08,9.61,;6.78,8.78,;6.85,7.24,;5.56,6.4,;5.63,4.87,;4.35,2.35,;3.37,1.16,;2.68,2.53,;1.14,2.62,;.3,1.33,;.99,-.05,;2.53,-.13,;2.29,.9,;1.83,1.82,)|
SMILES:C1N=C(Nc2cc3ccccc3cn2)O[C@]11C[N@@]2CC[C@H]1CC2 |wD:15.16,17.26,20.24,t:1,(4.2,-.14,;5.69,.25,;5.78,1.79,;7.08,2.62,;7,4.16,;8.3,4.99,;8.22,6.53,;9.52,7.37,;9.44,8.9,;8.08,9.61,;6.78,8.78,;6.85,7.24,;5.56,6.4,;5.63,4.87,;4.35,2.35,;3.37,1.16,;2.68,2.53,;1.14,2.62,;.3,1.33,;.99,-.05,;2.53,-.13,;2.29,.9,;1.83,1.82,)|

BMS-902483 is a potent α7 partial agonist. BMS-902483 improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm.

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