Name: BMS-933043
Rating: 5 (10 reviews)

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HIT ID:HIT212712292
Cas No:1221973-93-8
常用名:BMS-933043
别名:BMS933043
IUPAC:(2R)-N-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxazol]-5'-amine
IUPAC:(2R)-N-[6-(1H-imidazol-1-yl)pyrimidin-4-yl]-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxazol]-5'-amine
InChI key:RLXBHTUZCPORKT-INIZCTEOSA-N

分子式:C16H19N7O
分子量:325.376
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:1.1899801
SMILES:C1N=C(Nc2cc(ncn2)-n2ccnc2)O[C@]11CN2CCC1CC2 |t:1|
SMILES:C1N=C(Nc2cc(ncn2)-n2ccnc2)O[C@]11CN2CCC1CC2 |t:1|

BMS-933043 is a Selective α7 nAChR partial agonist. BMS-933043 showed potent binding affinity to native rat (Ki = 3.3 nM) and recombinant human alpha7 nicotinic acetylcholine receptors (Ki = 8.1 nM). BMS-933043 shows agonist activity in a calcium fluorescence assay (EC50 = 23.4 nM) and whole cell voltage clamp electrophysiology (EC50 = 0.14 μM (rat) and 0.29 μM (human)).

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