Name: BRD0476
Rating: 5 (10 reviews)

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sdf 文件

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类似物检索

HIT ID:HIT212712318
Cas No:1314958-91-2
常用名:BRD0476
别名:ML-187, ML187, ML 187, BRD-0476, BRD 0476
别名:ML-187, ML187, ML 187, BRD-0476, BRD 0476
IUPAC:1-[(2R,3R)-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-2-[(N-methyl2,3-dihydro-1,4-benzodioxine-6-sulfonamido)methyl]-6-oxo-3,4,5,6-tetrahydro-2H-1,5-benzoxazocin-10-yl]-3-(naphthalen-1-yl)urea
IUPAC:1-[(2R,3R)-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-2-[(N-methyl2,3-dihydro-1,4-benzodioxine-6-sulfonamido)methyl]-6-oxo-3,4,5,6-tetrahydro-2H-1,5-benzoxazocin-10-yl]-3-(naphthalen-1-yl)urea
InChI key:YDFFDCBBGWXONN-MODXFSQWSA-N

分子式:C35H38N4O8S
分子量:674.77
氢键供体数 (HBD):3
氢键受体数 (HBA):8
LogP:3.7706878
SMILES:C[C@@H](CO)N1C[C@@H](C)[C@H](CN(C)S(=O)(=O)c2ccc3OCCOc3c2)Oc2c(NC(=O)Nc3cccc4ccccc34)cccc2C1=O
SMILES:C[C@@H](CO)N1C[C@@H](C)[C@H](CN(C)S(=O)(=O)c2ccc3OCCOc3c2)Oc2c(NC(=O)Nc3cccc4ccccc34)cccc2C1=O

BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT signaling without suppressing the kinase activity of any JAK.

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