Ceralasertib formate | Ceralasertib | AZD-6738 | AZD6738 | AZD 6738 | CAS 1352280-98-8 | AnyMole

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HIT212712343

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HIT212712343

HIT ID:HIT212712343
Cas No:1352280-98-8
常用名:Ceralasertib formate
别名:Ceralasertib, AZD-6738, AZD6738, AZD 6738
别名:Ceralasertib, AZD-6738, AZD6738, AZD 6738
IUPAC:(R)-imino(methyl)(1-{6-[(3R)-3-methylmorpholin-4-yl]-2-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyrimidin-4-yl}cyclopropyl)-lambda6-sulfanone; formic acid
IUPAC:(R)-imino(methyl)(1-{6-[(3R)-3-methylmorpholin-4-yl]-2-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyrimidin-4-yl}cyclopropyl)-lambda6-sulfanone; formic acid
InChI key:JOKLXYXIZOXQHY-FQAMYIAXSA-N

分子式:C21H26N6O4S
分子量:458.54
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:2.259731
SMILES:OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O
SMILES:OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O

Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.

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供应商
TargetMolSC
规格
货期
6-8周
纯度
-
¥ 10,600.00
1

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