Name: CHS-111
Rating: 5 (10 reviews)

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HIT ID:HIT212712372
Cas No:886755-63-1
常用名:CHS-111
别名:CHS 111
IUPAC:[4-(2-benzyl-2H-indazol-3-yl)phenyl]methanol
IUPAC:[4-(2-benzyl-2H-indazol-3-yl)phenyl]methanol
InChI key:GUQSBGZNHKRJGO-UHFFFAOYSA-N

分子式:C21H18N2O
分子量:314.388
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:4.3007827
SMILES:OCc1ccc(cc1)-c1n(Cc2ccccc2)nc2ccccc12
SMILES:OCc1ccc(cc1)-c1n(Cc2ccccc2)nc2ccccc12

CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.

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