CJ-15208 | CJ-15,208 | CJ15,208 | CJ 15,208.c[Phe-D-Pro-Phe-Trp] | CAS 210236-47-8 | AnyMole

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HIT212712382

sdf 文件

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HIT212712382

HIT ID:HIT212712382
Cas No:210236-47-8
常用名:CJ-15208
别名:CJ-15,208, CJ15,208, CJ 15,208.c[Phe-D-Pro-Phe-Trp]
别名:CJ-15,208, CJ15,208, CJ 15,208.c[Phe-D-Pro-Phe-Trp]
IUPAC:(3S,6S,9S,14aR)-3,9-dibenzyl-6-[(1H-indol-3-yl)methyl]-tetradecahydropyrrolo[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
IUPAC:(3S,6S,9S,14aR)-3,9-dibenzyl-6-[(1H-indol-3-yl)methyl]-tetradecahydropyrrolo[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
InChI key:GIZJWWQFOGQPRY-GCXHJFECSA-N

分子式:C34H35N5O4
分子量:577.685
氢键供体数 (HBD):4
氢键受体数 (HBA):4
LogP:3.1943307
SMILES:O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]12
SMILES:O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]12

CJ-15208 is a potent and selective κ-opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502 (IC50 are 47 nM for kappa, 260 nM for mu, and 2,600 nM for delta respectly). In the electrically-stimulated twitch response assay of rabbit vas deferens, CJ-15208 recovered the suppression by a kappa agonist asimadoline with an ED50 of 1.3 microM.

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供应商
TargetMolSC
规格
货期
3-6月
纯度
-
待询
1

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