DCB-3503 | NSC-716802 | NSC716802 | NSC 716802 | DCB3503 | DCB 3503 | CAS 87302-58-7 | AnyMole

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HIT212712465

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HIT212712465

HIT ID:HIT212712465
Cas No:87302-58-7
常用名:DCB-3503
别名:NSC-716802, NSC716802, NSC 716802, DCB3503, DCB 3503
别名:NSC-716802, NSC716802, NSC 716802, DCB3503, DCB 3503
IUPAC:(20S,21S)-4,5,10,11-tetramethoxy-16-azapentacyclo[12.7.0.0^{2,7}.0^{8,13}.0^{16,20}]henicosa-1(14),2(7),3,5,8(13),9,11-heptaen-21-ol
IUPAC:(20S,21S)-4,5,10,11-tetramethoxy-16-azapentacyclo[12.7.0.0^{2,7}.0^{8,13}.0^{16,20}]henicosa-1(14),2(7),3,5,8(13),9,11-heptaen-21-ol
InChI key:JWHWLMNMGLICQZ-MHECFPHRSA-N

分子式:C24H27NO5
分子量:409.482
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:2.8493679
SMILES:[H][C@@]12CCCN1Cc1c([C@@H]2O)c2cc(OC)c(OC)cc2c2cc(OC)c(OC)cc12
SMILES:[H][C@@]12CCCN1Cc1c([C@@H]2O)c2cc(OC)c(OC)cc2c2cc(OC)c(OC)cc12

Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
8-10周
纯度
-
¥ 13,900.00
1

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