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HIT212712484
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HIT212712484
  • HIT ID:HIT212712484
  • Cas No:1262440-25-4
  • 常用名:Dezapelisib
  • 别名:INCB-040093, INCB040093, INCB 040093
  • IUPAC:6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    IUPAC:6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
  • InChI key:RSIWALKZYXPAGW-NSHDSACASA-N
  • 分子式:C20H16FN7OS
  • 分子量:421.45
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):6
  • LogP:2.7610824
  • SMILES:C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
    SMILES:C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
  • Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K). INCB040093 prevents both the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in PI3K-overexpressing tumor cells.
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  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 12,800.00
    1

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