Name: Dihydrocelastrol
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT212712503
Cas No:193957-88-9
常用名:Dihydrocelastrol
别名:Triptohypol C, DHCE. (-)-Triptohypol C
IUPAC:(2R,4aS,6aS,12bS,14aS,14bR)-10,11-dihydroxy-2,4a,6a,9,12b,14a-hexamethyl-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
IUPAC:(2R,4aS,6aS,12bS,14aS,14bR)-10,11-dihydroxy-2,4a,6a,9,12b,14a-hexamethyl-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
InChI key:WZAUFGYINZYCKH-JJWQIEBTSA-N

分子式:C29H40O4
分子量:452.635
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:6.903507
SMILES:Cc1c(O)c(O)cc2c1CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |c:11|
SMILES:Cc1c(O)c(O)cc2c1CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |c:11|

Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the ERK1/2 and IL-6/STAT3 pathways.

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