Name: DNS-8254
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212712521
Cas No:1821107-98-5
常用名:DNS-8254
IUPAC:(5S)-1-(3-bromo-4-fluorobenzoyl)-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
IUPAC:(5S)-1-(3-bromo-4-fluorobenzoyl)-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
InChI key:TTWAYHJJEHLVNR-LBPRGKRZSA-N

分子式:C18H15BrF3N5O
分子量:454.251
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:2.7355356
SMILES:[H][C@]1(CN(CC(F)(F)C1)C(=O)c1ccc(F)c(Br)c1)c1cc(C)nc2ncnn12
SMILES:[H][C@]1(CN(CC(F)(F)C1)C(=O)c1ccc(F)c(Br)c1)c1cc(C)nc2ncnn12

DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) inhibitor for the treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object recognition.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~