Name: DS-8587
Rating: 5 (10 reviews)

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HIT ID:HIT212712534
Cas No:1356918-39-2
常用名:DS-8587
别名:DS-8587 free, DS8587, DS 8587
IUPAC:7-[(3aR,6aS)-3a-amino-6a-fluoro-octahydrocyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dihydrate hydrochloride
IUPAC:7-[(3aR,6aS)-3a-amino-6a-fluoro-octahydrocyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dihydrate hydrochloride
InChI key:WDCLSNJDBKODOF-JNEZQIAFSA-N

分子式:C21H27ClF3N3O5
分子量:493.91
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:0.20625067
SMILES:O.O.Cl.Cc1c(N2C[C@]3(N)CCC[C@]3(F)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F
SMILES:O.O.Cl.Cc1c(N2C[C@]3(N)CCC[C@]3(F)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F

DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587.

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