Name: Ensaculin HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212712582
Cas No:209969-60-8
常用名:Ensaculin HCl
别名:KA-672 HCl, KA672 HCl, KA 672 HCl, Ensaculin Hydrochloride, Anseculin Hydrochloride
别名:KA-672 HCl, KA672 HCl, KA 672 HCl, Ensaculin Hydrochloride, Anseculin Hydrochloride
IUPAC:7-methoxy-6-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-3,4-dimethyl-2H-chromen-2-one hydrochloride
IUPAC:7-methoxy-6-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-3,4-dimethyl-2H-chromen-2-one hydrochloride
InChI key:XMONKHCPLIYQCY-UHFFFAOYSA-N

分子式:C26H33ClN2O5
分子量:489.01
氢键供体数 (HBD):0
氢键受体数 (HBA):6
LogP:3.822135
SMILES:Cl.COc1cc2oc(=O)c(C)c(C)c2cc1OCCCN1CCN(CC1)c1ccccc1OC
SMILES:Cl.COc1cc2oc(=O)c(C)c(C)c2cc1OCCCN1CCN(CC1)c1ccccc1OC

Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT(1A) and 5-HT(7) receptors, adrenergic alpha(1), and dopaminergic D(2) and D(3) receptors.

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