Name: FK-739 free acid
Rating: 5 (10 reviews)

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HIT ID:HIT212712632
Cas No:133052-30-9
常用名:FK-739 free acid
别名:FK-739, FK739, FK 739
IUPAC:5-[4'-({2-butyl-3H-imidazo[4,5-b]pyridin-3-yl}methyl)-[1,1'-biphenyl]-2-yl]-2H-1,2,3,4-tetrazole
IUPAC:5-[4'-({2-butyl-3H-imidazo[4,5-b]pyridin-3-yl}methyl)-[1,1'-biphenyl]-2-yl]-2H-1,2,3,4-tetrazole
InChI key:YILJWHUIUCRKEU-UHFFFAOYSA-N

分子式:C24H23N7
分子量:409.497
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:5.7150674
SMILES:CCCCc1nc2cccnc2n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
SMILES:CCCCc1nc2cccnc2n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1

FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebellum membrane.

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