Name: Fonsartan free acid
Rating: 5 (10 reviews)

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HIT ID:HIT212712652
Cas No:144628-52-4
常用名:Fonsartan free acid
别名:HR-720, HR720, HOE-720, HOE720
IUPAC:2-butyl-4-(methylsulfanyl)-1-[(2'-{[(propylcarbamoyl)amino]sulfonyl}-[1,1'-biphenyl]-4-yl)methyl]-1H-imidazole-5-carboxylic acid
IUPAC:2-butyl-4-(methylsulfanyl)-1-[(2'-{[(propylcarbamoyl)amino]sulfonyl}-[1,1'-biphenyl]-4-yl)methyl]-1H-imidazole-5-carboxylic acid
InChI key:DKCCTYVLJMSFOG-UHFFFAOYSA-N

分子式:C26H32N4O5S2
分子量:544.69
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:4.363635
SMILES:CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCCC
SMILES:CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCCC

Fonsartan is an angiotensin receptor antagonist. Fonsartan inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.

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