Name: GS-462808
Rating: 5 (10 reviews)

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HIT ID:HIT212712729
Cas No:1354198-41-6
常用名:GS-462808
别名:GS462808, GS 462808
IUPAC:2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
IUPAC:2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
InChI key:CIUYUJJQZDDGTM-UHFFFAOYSA-N

分子式:C17H12F3N5O3
分子量:391.31
氢键供体数 (HBD):0
氢键受体数 (HBA):5
LogP:5.0443
SMILES:Cc1noc(Cn2nc3ccc(cn3c2=O)-c2ccc(OC(F)(F)F)cc2)n1
SMILES:Cc1noc(Cn2nc3ccc(cn3c2=O)-c2ccc(OC(F)(F)F)cc2)n1

GS-462808 is a late sodium current inhibitor of the cardiac Nav1.5 channel. GS-462808 had lower brain penetration and serendipitously lower activity at the brain isoforms.

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