Name: GSK 224876
Rating: 5 (10 reviews)

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HIT ID:HIT212712734
Cas No:1097733-15-7;1018450-26-4
常用名:GSK 224876
别名:GSK-224876, GSK224876
IUPAC:(R)-(methyl (2-carbamoyl-5-chloro-1H-indol-3-yl)({3-[(1E)-2-cyanoeth-1-en-1-yl]-5-methylphenyl})phosphinate)
IUPAC:(R)-(methyl (2-carbamoyl-5-chloro-1H-indol-3-yl)({3-[(1E)-2-cyanoeth-1-en-1-yl]-5-methylphenyl})phosphinate)
InChI key:CGBYTKOSZYQOPV-ASSBYYIWSA-N

分子式:C20H17ClN3O3P
分子量:413.8
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:3.5386
SMILES:CO[P@@](=O)(c1c([nH]c2ccc(Cl)cc12)C(N)=O)c1cc(C)cc(\C=C\C#N)c1
SMILES:CO[P@@](=O)(c1c([nH]c2ccc(Cl)cc12)C(N)=O)c1cc(C)cc(\C=C\C#N)c1

GSK 224876 is a novel next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). It has activity against efavirenz-resistant strains in the treatment of treatment-naive HIV-1-infected subjects.

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