Name: GSK-215083
Rating: 5 (10 reviews)

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HIT ID:HIT212712743
Cas No:607742-80-3
常用名:GSK-215083
别名:GSK215083
IUPAC:3-(3-fluorobenzenesulfonyl)-8-(4-methylpiperazin-1-yl)quinoline
IUPAC:3-(3-fluorobenzenesulfonyl)-8-(4-methylpiperazin-1-yl)quinoline
InChI key:PXVJEDOZGDZJQY-UHFFFAOYSA-N

分子式:C20H20FN3O2S
分子量:385.46
氢键供体数 (HBD):0
氢键受体数 (HBA):5
LogP:3.1836004
SMILES:CN1CCN(CC1)c1cccc2cc(cnc12)S(=O)(=O)c1cccc(F)c1
SMILES:CN1CCN(CC1)c1cccc2cc(cnc12)S(=O)(=O)c1cccc(F)c1

GSK-215083 is a PET radioligand for the 5-HT6 receptor. GSK 215083 is a quinoline based compounds and acts by antagonising the 5-HT6 receptor. GSK-215083 binds to receptors 5-hydroxytrypamine-6 (5HT6) in the striatum and 5-hydroxytryptamine-2A (5HT2A) in the frontal cortex.

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