Name: GW-3333
Rating: 5 (10 reviews)

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HIT ID:HIT212712790
Cas No:212609-68-2
常用名:GW-3333
别名:GW3333, GW 3333
IUPAC:(2R,3S)-3-(N-hydroxyformamido)-4-methyl-N-[(1S,2S)-2-methyl-1-[(pyridin-2-yl)carbamoyl]butyl]-2-(2-methylpropyl)pentanamide
IUPAC:(2R,3S)-3-(N-hydroxyformamido)-4-methyl-N-[(1S,2S)-2-methyl-1-[(pyridin-2-yl)carbamoyl]butyl]-2-(2-methylpropyl)pentanamide
InChI key:SMZPWUUYPYYHIV-HNJRGHQBSA-N

分子式:C22H36N4O4
分子量:420.554
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.4863482
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)[C@H](C(C)C)N(O)C=O)C(=O)Nc1ccccn1
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)[C@H](C(C)C)N(O)C=O)C(=O)Nc1ccccn1

GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiarthritics.

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