Name: INU-152
Rating: 5 (10 reviews)

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HIT ID:HIT212712825
Cas No:1380228-30-7
常用名:INU-152
IUPAC:N-(2,4-difluoro-3-{[3-(9H-purin-6-yl)pyridin-2-yl]amino}phenyl)furan-3-sulfonamide
IUPAC:N-(2,4-difluoro-3-{[3-(9H-purin-6-yl)pyridin-2-yl]amino}phenyl)furan-3-sulfonamide
InChI key:ACIXGVIVJZJKNT-UHFFFAOYSA-N

分子式:C20H13F2N7O3S
分子量:469.43
氢键供体数 (HBD):3
氢键受体数 (HBA):7
LogP:2.602
SMILES:Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
SMILES:Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

INU-152 is a pan-RAF inhibitor. INU-152 has potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS.

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