Name: II-B08
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212712865
Cas No:1143579-78-5
常用名:II-B08
别名:Lyp Inhibitor III, LMWPTP Inhibitor, II-B-08, II-B 08, FAP1 Inhibitor, CD45 Inhibitor V
别名:Lyp Inhibitor III, LMWPTP Inhibitor, II-B-08, II-B 08, FAP1 Inhibitor, CD45 Inhibitor V
IUPAC:3-{1-[2-({[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
IUPAC:3-{1-[2-({[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
InChI key:RATFAFAWIWHLMR-UHFFFAOYSA-N

分子式:C33H27N5O4
分子量:557.61
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:6.743511
SMILES:Cn1c(c(-c2cn(CCC(=O)Nc3ccc(cc3)-c3ccccc3)nn2)c2cc(C(O)=O)c(O)cc12)-c1ccccc1
SMILES:Cn1c(c(-c2cn(CCC(=O)Nc3ccc(cc3)-c3ccccc3)nn2)c2cc(C(O)=O)c(O)cc12)-c1ccccc1

II-B08 is a cell-permeable SHP2 inhibitor (IC50 = 5.5 µM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.

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