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  3. HIT212712953
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HIT212712953
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HIT212712953
  • HIT ID:HIT212712953
  • Cas No:247131-79-9
  • 常用名:JTV-803 mesylate
  • 别名:JTV-803, JTV803, JTV 803
  • IUPAC:4-{[(2-carbamimidoyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy]methyl}-1-(pyridin-4-yl)piperidine-4-carboxylic acid; methanesulfonic acid
    IUPAC:4-{[(2-carbamimidoyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy]methyl}-1-(pyridin-4-yl)piperidine-4-carboxylic acid; methanesulfonic acid
  • InChI key:NOBZETMXGVAWIM-UHFFFAOYSA-N
  • 分子式:C23H31N5O6S
  • 分子量:505.59
  • 氢键供体数 (HBD):3
  • 氢键受体数 (HBA):8
  • LogP:-0.0316629
  • SMILES:CS(O)(=O)=O.NC(=N)N1CCc2ccc(OCC3(CCN(CC3)c3ccncc3)C(O)=O)cc2C1
    SMILES:CS(O)(=O)=O.NC(=N)N1CCc2ccc(OCC3(CCN(CC3)c3ccncc3)C(O)=O)cc2C1
  • JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting human factor Xa as compared to its inhibitory activity against thrombin, trypsin and plasmin. JTV-803 prolonged activated partial thromboplastin time and prothrombin time in a dose-dependent manner.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 15,000.00
    1

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