Name: L-796568 dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212713038
Cas No:211031-81-1
常用名:L-796568 dihydrochloride
别名:L-796568, L796568, L 796568
IUPAC:N-[4-(2-{[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]amino}ethyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzene-1-sulfonamide dihydrochloride
IUPAC:N-[4-(2-{[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]amino}ethyl)phenyl]-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzene-1-sulfonamide dihydrochloride
InChI key:CANSTXQBARAFMV-UJXPALLWSA-N

分子式:C31H29Cl2F3N4O3S2
分子量:697.61
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:4.778512
SMILES:Cl.Cl.O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1)c1cccnc1
SMILES:Cl.Cl.O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1)c1cccnc1

L-796568, is a β3 adrenergic receptor agonist. L-796568 is a potent full beta(3) agonist (EC(50) = 3.6 nM, 94% activation) with >600-fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavailability in several mammalian species, as well as an extended duration of action.

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