Name: ONO-0300302
Rating: 5 (10 reviews)

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HIT ID:HIT212713191
Cas No:856689-51-5
常用名:ONO-0300302
别名:ONO 0300302
IUPAC:3-{1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrol-3-yl}propanoic acid
IUPAC:3-{1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrol-3-yl}propanoic acid
InChI key:USAXUWZJQPBEDO-ABYGYWHVSA-N

分子式:C29H35NO5
分子量:477.601
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:5.550279
SMILES:COc1cc(cc(OC)c1C)[C@@H](O)[C@@H](CC1Cc2ccccc2C1)Cn1ccc(CCC(O)=O)c1
SMILES:COc1cc(cc(OC)c1C)[C@@H](O)[C@@H](CC1Cc2ccccc2C1)Cn1ccc(CCC(O)=O)c1

ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h.

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