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  3. HIT212713199
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HIT212713199
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HIT212713199
  • HIT ID:HIT212713199
  • Cas No:123288-47-1
  • 常用名:ONO-8809
  • 别名:ONO8809
  • IUPAC:decyl (5Z)-6-[(1S,2S,3R,4R)-3-[(4-bromobenzenesulfonamido)methyl]bicyclo[2.2.1]heptan-2-yl]hex-5-enoate
    IUPAC:decyl (5Z)-6-[(1S,2S,3R,4R)-3-[(4-bromobenzenesulfonamido)methyl]bicyclo[2.2.1]heptan-2-yl]hex-5-enoate
  • InChI key:KLMMNRLRCVRTDN-IVMBPFMGSA-N
  • 分子式:C30H46BrNO4S
  • 分子量:596.67
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):3
  • LogP:8.316636
  • SMILES:[H][C@@]12CC[C@@]([H])(C1)[C@@H](\C=C/CCCC(=O)OCCCCCCCCCC)[C@@H]2CNS(=O)(=O)c1ccc(Br)cc1
    SMILES:[H][C@@]12CC[C@@]([H])(C1)[C@@H](\C=C/CCCC(=O)OCCCCCCCCCC)[C@@H]2CNS(=O)(=O)c1ccc(Br)cc1
  • ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area in the contralateral cerebral cortex to the stroke lesion of salt-loaded SHRSP and 8-iso-PGF2alpha-treated SHRSP were significantly reduced by ONO-8809 treatment.
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  • 供应商
    TargetMolSC
    规格
    货期
    3-6月
    纯度
    -
    待询
    1

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