Name: OSI-296
Rating: 5 (10 reviews)

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HIT ID:HIT212713219
Cas No:1175296-94-2
常用名:OSI-296
IUPAC:4-{6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl}-1,2,3,6-tetrahydropyridine-1-carboxamide
IUPAC:4-{6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl}-1,2,3,6-tetrahydropyridine-1-carboxamide
InChI key:LVYXERPKYAQGKM-SNVBAGLBSA-N

分子式:C21H19Cl2FN4O3
分子量:465.31
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.2849195
SMILES:C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl |t:15|
SMILES:C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl |t:15|

OSI-296 is a potent and dual inhibitor of cMET and RON kinases (IC50 value are 42 nM and 200 nM for cMet and sfRon respectively) . OSI-206 shows in vivo efficacy and is well tolerated in tumor xenografts models upon oral dosing. OSI-296 also reduces tumour growth in the bone.

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