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  3. HIT212713223
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HIT212713223
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HIT212713223
  • HIT ID:HIT212713223
  • Cas No:1480830-24-7
  • 常用名:OUP-186
  • 别名:OUP186
  • IUPAC:N-[4-(4-chlorophenyl)butyl]{[3-(piperidin-1-yl)propyl]sulfanyl}methanimidamide
    IUPAC:N-[4-(4-chlorophenyl)butyl]{[3-(piperidin-1-yl)propyl]sulfanyl}methanimidamide
  • InChI key:BEAOCYNTOAGFPE-UHFFFAOYSA-N
  • 分子式:C19H30ClN3S
  • 分子量:367.98
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:5.0225787
  • SMILES:Clc1ccc(CCCCNC(=N)SCCCN2CCCCC2)cc1
    SMILES:Clc1ccc(CCCCNC(=N)SCCCN2CCCCC2)cc1
  • OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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