Name: PF-04628935
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT212713311
Cas No:1383719-97-8
常用名:PF-04628935
别名:PF-4628935, PF4628935, PF04628935, PF 4628935, PF 04628935
别名:PF-4628935, PF4628935, PF04628935, PF 4628935, PF 04628935
IUPAC:1-(2-{[2-chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl}-2,7-diazaspiro[3.5]nonan-7-yl)-2-{2-methylimidazo[2,1-b][1,3]thiazol-6-yl}ethan-1-one
IUPAC:1-(2-{[2-chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl}-2,7-diazaspiro[3.5]nonan-7-yl)-2-{2-methylimidazo[2,1-b][1,3]thiazol-6-yl}ethan-1-one
InChI key:MTDYDDJVCIHZKH-UHFFFAOYSA-N

分子式:C24H26ClN7OS
分子量:496.03
氢键供体数 (HBD):0
氢键受体数 (HBA):5
LogP:2.7916
SMILES:Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1
SMILES:Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1

PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. PF-04628935 is orally bioavailable and brain penetrant.

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