Name: PF-06278121
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212713314
Cas No:1402438-37-2
常用名:PF-06278121
别名:PF-6278121, PF6278121, PF 6278121
IUPAC:N-(5-{7-[(2S)-1-hydroxypropan-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}pyridin-3-yl)-2-[4-(trifluoromethyl)phenyl]acetamide
IUPAC:N-(5-{7-[(2S)-1-hydroxypropan-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}pyridin-3-yl)-2-[4-(trifluoromethyl)phenyl]acetamide
InChI key:FFWLYMMISQUEAL-AWEZNQCLSA-N

分子式:C24H20F3N5O3
分子量:483.451
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:2.657688
SMILES:C[C@@H](CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12
SMILES:C[C@@H](CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12

PF-06278121 is a potent and selective Trk inhibitor. PF-06278121 shows Trk A/B IC50 = 4/94 nM (enzymatic assay), Trk A/B/C IC50 = 13/7/6 nM (PathHunter cell assay).

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