Name: PF-06456384
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212713316
Cas No:1834610-73-9
常用名:PF-06456384
别名:PF-6456384, PF6456384, PF06456384, PF 6456384, PF 06456384
别名:PF-6456384, PF6456384, PF06456384, PF 6456384, PF 06456384
IUPAC:3-cyano-4-({3-[2-({[2-(piperidin-4-yl)ethyl]amino}methyl)pyridin-4-yl]-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl}oxy)-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide
IUPAC:3-cyano-4-({3-[2-({[2-(piperidin-4-yl)ethyl]amino}methyl)pyridin-4-yl]-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl}oxy)-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide
InChI key:WSPHMGORSRQULF-UHFFFAOYSA-N

分子式:C35H32F3N7O3S2
分子量:719.8
氢键供体数 (HBD):3
氢键受体数 (HBA):8
LogP:4.8701754
SMILES:FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1
SMILES:FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1

PF-06456384 is a highly potent and selective NaV1.7 inhibitor with IC50 value of 0.01 nM.

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