Name: PF-6422899
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212713337
Cas No:1621002-23-0
常用名:PF-6422899
别名:PF6422899, PF 6422899
IUPAC:N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(prop-2-yn-1-yloxy)quinazolin-6-yl}prop-2-enamide
IUPAC:N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(prop-2-yn-1-yloxy)quinazolin-6-yl}prop-2-enamide
InChI key:AZLXGJFHSLQCPV-UHFFFAOYSA-N

分子式:C20H14ClFN4O2
分子量:396.81
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:4.2706075
SMILES:Fc1ccc(Nc2ncnc3cc(OCC#C)c(NC(=O)C=C)cc23)cc1Cl
SMILES:Fc1ccc(Nc2ncnc3cc(OCC#C)c(NC(=O)C=C)cc23)cc1Cl

PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.

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