Name: Phenoprolamine Hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212713343
Cas No:93933-71-2
常用名:Phenoprolamine Hydrochloride
别名:phenoprolamine Hydrochloride, Hydrochloride
别名:phenoprolamine Hydrochloride, Hydrochloride
IUPAC:[2-(3,4-dimethoxyphenyl)ethyl][1-(2,6-dimethylphenoxy)propan-2-yl]amine hydrochloride
IUPAC:[2-(3,4-dimethoxyphenyl)ethyl][1-(2,6-dimethylphenoxy)propan-2-yl]amine hydrochloride
InChI key:KNMNNEPMKDJBDW-UHFFFAOYSA-N

分子式:C21H30ClNO3
分子量:379.93
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.5923805
SMILES:Cl.COc1ccc(CCNC(C)COc2c(C)cccc2C)cc1OC
SMILES:Cl.COc1ccc(CCNC(C)COc2c(C)cccc2C)cc1OC

Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-regulates their mRNA transcription and protein expression. Phenoprolamine Hydrochloride can efficiently penetrate through blood brain barrier and inhibit the contraction of vascular smooth muscle in the brain.

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