Name: ProTAME
Rating: 5 (10 reviews)

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HIT ID:HIT212713384
Cas No:1362911-19-0
常用名:ProTAME
别名:pro-Tosyl-L-Arginine Methyl Ester
IUPAC:methyl (2S)-2-(4-methylbenzenesulfonamido)-5-{[(E)-[({[(2-phenylacetyl)oxy]methoxy}carbonyl)amino][({[(2-phenylacetyl)oxy]methoxy}carbonyl)imino]methyl]amino}pentanoate
IUPAC:methyl (2S)-2-(4-methylbenzenesulfonamido)-5-{[(E)-[({[(2-phenylacetyl)oxy]methoxy}carbonyl)amino][({[(2-phenylacetyl)oxy]methoxy}carbonyl)imino]methyl]amino}pentanoate
InChI key:MHYOVHULCQSDRZ-NDEPHWFRSA-N

分子式:C34H38N4O12S
分子量:726.75
氢键供体数 (HBD):3
氢键受体数 (HBA):8
LogP:5.037236
SMILES:COC(=O)[C@H](CCCN\C(NC(=O)OCOC(=O)Cc1ccccc1)=N/C(=O)OCOC(=O)Cc1ccccc1)NS(=O)(=O)c1ccc(C)cc1
SMILES:COC(=O)[C@H](CCCN\C(NC(=O)OCOC(=O)Cc1ccccc1)=N/C(=O)OCOC(=O)Cc1ccccc1)NS(=O)(=O)c1ccc(C)cc1

ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell lines, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.This compound is unstable in powder form and other related salt forms are recommended.

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