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  3. HIT212713430
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HIT212713430
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HIT212713430
  • HIT ID:HIT212713430
  • Cas No:1884226-20-3
  • 常用名:REDX05358
  • 别名:REDX-05358, REDX 05358
  • IUPAC:5-({3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one
    IUPAC:5-({3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one
  • InChI key:KPSFBIACWSYKON-UHFFFAOYSA-N
  • 分子式:C26H21ClN4O3
  • 分子量:472.93
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):4
  • LogP:4.471586
  • SMILES:Clc1ccccc1-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
    SMILES:Clc1ccccc1-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
  • REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates subnanomolar binding affinity for BRAF and CRAF with high selectivity profile against a panel of 468 kinases that exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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