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  3. HIT212713446
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HIT212713446
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HIT212713446
  • HIT ID:HIT212713446
  • Cas No:2109450-40-8
  • 常用名:RN-9893 (hydrochloride)
  • IUPAC:2-nitro-N-(4-{[4-(propan-2-yl)piperazin-1-yl]sulfonyl}phenyl)-4-(trifluoromethyl)benzamide hydrochloride
    IUPAC:2-nitro-N-(4-{[4-(propan-2-yl)piperazin-1-yl]sulfonyl}phenyl)-4-(trifluoromethyl)benzamide hydrochloride
  • InChI key:ULUOUAGDTULBRZ-UHFFFAOYSA-N
  • 分子式:C21H24ClF3N4O5S
  • 分子量:536.95
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):6
  • LogP:3.5568488
  • SMILES:Cl.CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
    SMILES:Cl.CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
  • RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays).
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    TargetMolSC
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    35日内发货
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    ¥ 862.00
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