Name: RX-37
Rating: 5 (10 reviews)

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HIT ID:HIT212713535
Cas No:1627715-60-9
常用名:RX-37
别名:RX37
IUPAC:4-[1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl]-3,5-dimethyl-1,2-oxazole
IUPAC:4-[1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl]-3,5-dimethyl-1,2-oxazole
InChI key:WHDUHJYPRJXLGF-UHFFFAOYSA-N

分子式:C24H23N5O2
分子量:413.481
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.5062315
SMILES:COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
SMILES:COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21

RX-37 is a potent BET inhibitor with Ki values of 3.2-24.7 nM for BRD2, BRD3 and BRD4. RX-37 demonstrates high selectivity over other non-BET bromodomain-containing proteins. RX-37 potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged mixed lineage leukemia 1 gene.

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