Name: SRA880 free base
Rating: 5 (10 reviews)

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HIT ID:HIT212713729
Cas No:187218-90-2
常用名:SRA880 free base
别名:SRA-880, SRA880, SRA 880, NVP-SRA880, NVPSRA880, NVP SRA880
别名:SRA-880, SRA880, SRA 880, NVP-SRA880, NVPSRA880, NVP SRA880
IUPAC:1-[(3R,4aR,10aR)-6-methoxy-1-methyl-1H,2H,3H,4H,4aH,5H,10H,10aH-benzo[g]quinoline-3-carbonyl]-4-(4-nitrophenyl)piperazine
IUPAC:1-[(3R,4aR,10aR)-6-methoxy-1-methyl-1H,2H,3H,4H,4aH,5H,10H,10aH-benzo[g]quinoline-3-carbonyl]-4-(4-nitrophenyl)piperazine
InChI key:INULNSAIIZKOQE-YOSAUDMPSA-N

分子式:C26H32N4O4
分子量:464.566
氢键供体数 (HBD):0
氢键受体数 (HBA):6
LogP:3.6231508
SMILES:[H][C@]12C[C@H](CN(C)[C@]1([H])Cc1cccc(OC)c1C2)C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
SMILES:[H][C@]12C[C@H](CN(C)[C@]1([H])Cc1cccc(OC)c1C2)C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O

SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.

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