Name: T145
Rating: 5 (10 reviews)

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HIT ID:HIT212713764
Cas No:1021186-98-0
常用名:T145
别名:T-145, T 145
IUPAC:N-{[(5S)-3-(oxanthren-2-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
IUPAC:N-{[(5S)-3-(oxanthren-2-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
InChI key:CARSFZJMGZOXPN-ZDUSSCGKSA-N

分子式:C18H16N2O5
分子量:340.335
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:1.6317469
SMILES:CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc2Oc3ccccc3Oc2c1
SMILES:CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc2Oc3ccccc3Oc2c1

T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolongs longevity of a drug in clinical use.

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