Name: UK-122 TFA salt
Rating: 5 (10 reviews)

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HIT ID:HIT212713856
Cas No:1186653-73-5
常用名:UK-122 TFA salt
别名:uPA Inhibitor II, UK122 TFA salt, UK 122 TFA salt, K122 trifloroacetic acid
别名:uPA Inhibitor II, UK122 TFA salt, UK 122 TFA salt, K122 trifloroacetic acid
IUPAC:4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide; trifluoroacetic acid
IUPAC:4-{[(4E)-5-oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-ylidene]methyl}benzene-1-carboximidamide; trifluoroacetic acid
InChI key:KVCIDYPYQWLDKP-KMZJGFRYSA-N

分子式:C19H14F3N3O4
分子量:405.333
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:2.7608466
SMILES:OC(=O)C(F)(F)F.NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:15|
SMILES:OC(=O)C(F)(F)F.NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:15|

UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line.

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