Name: UR-3216
Rating: 5 (10 reviews)

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HIT ID:HIT212713874
Cas No:220386-65-2
常用名:UR-3216
IUPAC:ethyl 2-{5-[(2S)-2-({4-[(Z)-N'-hydroxycarbamimidoyl]phenyl}formamido)-3-(4-nitrophenyl)propanoyl]-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-2-yl}acetate
IUPAC:ethyl 2-{5-[(2S)-2-({4-[(Z)-N'-hydroxycarbamimidoyl]phenyl}formamido)-3-(4-nitrophenyl)propanoyl]-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-2-yl}acetate
InChI key:JFXRCSVTAOUYGR-QHCPKHFHSA-N

分子式:C27H29N7O7
分子量:563.571
氢键供体数 (HBD):3
氢键受体数 (HBA):9
LogP:1.451047
SMILES:CCOC(=O)Cn1cc2CN(CCc2n1)C(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccc(cc1)C(\N)=N\O
SMILES:CCOC(=O)Cn1cc2CN(CCc2n1)C(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccc(cc1)C(\N)=N\O

UR-3216, a prodrug, is a selective and orally active platelet surface glycoprotein (GPIIb/IIIa) receptor antagonist. UR-3216 is the very tight binding of its active metabolite to platelets (Ki for resting platelets is < 1 nM). UR-2992, the active form of UR-3216, binds to platelets for a long period of time, while the unbound drug is rapidly cleared.

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