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  3. HIT212713916
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HIT212713916
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HIT212713916
  • HIT ID:HIT212713916
  • Cas No:
  • 常用名:YD277
  • 别名:YD-277, YD 277
  • IUPAC:tert-butyl 4-{2-[(2E)-3-(3-chlorophenyl)prop-2-enamido]-N-methylacetamido}piperidine-1-carboxylate
    IUPAC:tert-butyl 4-{2-[(2E)-3-(3-chlorophenyl)prop-2-enamido]-N-methylacetamido}piperidine-1-carboxylate
  • InChI key:QLZYWUJZDBTGDC-CMDGGOBGSA-N
  • 分子式:C22H30ClN3O4
  • 分子量:435.95
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):3
  • LogP:2.2022085
  • SMILES:CN(C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)CNC(=O)\C=C\c1cccc(Cl)c1
    SMILES:CN(C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)CNC(=O)\C=C\c1cccc(Cl)c1
  • YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC cells, independent of KLF5 inhibition. YD277 also reduced the protein expression levels of Cyclin D1, Bcl2 and Bclxl and promoted the expression of p21 and p27. YD277 (15 mg/kg) significantly suppressed the growth of MDA-MB-231 tumor xenografts in nude mice.
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  • 供应商
    TargetMolSC
    规格
    货期
    3-6月
    纯度
    -
    待询
    1

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