Name: YM-430
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212713960
Cas No:153192-22-4
常用名:YM-430
别名:YM430, YM-15430-3, YM-15430-2, YM-15430-1, YM-154301, YM-15430
别名:YM430, YM-15430-3, YM-15430-2, YM-15430-1, YM-154301, YM-15430
IUPAC:3-(4-{[(2S)-2-hydroxy-3-phenoxypropyl]amino}butyl) 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC:3-(4-{[(2S)-2-hydroxy-3-phenoxypropyl]amino}butyl) 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChI key:HBXMSJLNXYLVTA-HOFKKMOUSA-N

分子式:C29H35N3O8
分子量:553.612
氢键供体数 (HBD):3
氢键受体数 (HBA):8
LogP:3.0421278
SMILES:COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCCNC[C@H](O)COc1ccccc1 |c:4,9|
SMILES:COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCCNC[C@H](O)COc1ccccc1 |c:4,9|

YM-430 is a β1 adrenergic receptor antagonist and a calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO.

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