Name: YM-543 trimethylamine
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212713965
Cas No:918802-70-7;1610007-47-0
常用名:YM-543 trimethylamine
别名:ASP-543, ASP543, ASP 543
IUPAC:(2-hydroxyethyl)trimethylazanium 4-[(azulen-2-yl)methyl]-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzen-1-olate
IUPAC:(2-hydroxyethyl)trimethylazanium 4-[(azulen-2-yl)methyl]-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzen-1-olate
InChI key:UKOOBSDARBTSHN-NGOMLPPMSA-M

分子式:C28H37NO7
分子量:499.604
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:1.9936304
SMILES:C[N+](C)(C)CCO.OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2cc3cccccc3c2)ccc1[O-]
SMILES:C[N+](C)(C)CCO.OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2cc3cccccc3c2)ccc1[O-]

YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK/Ay type 2 diabetic mice, effects that were sustained even after 12 h.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~