Name: Z060228
Rating: 5 (10 reviews)

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HIT ID:HIT212713973
Cas No:1005459-82-4
常用名:Z060228
别名:Z-060228, Z 060228
IUPAC:ethyl (4R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2,4,6-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate
IUPAC:ethyl (4R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2,4,6-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate
InChI key:KJMMHIXCAAJWNO-SFHVURJKSA-N

分子式:C20H15ClF4N2O2
分子量:426.8
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:4.7266364
SMILES:CCOC(=O)C1=C(C)NC(=N[C@H]1c1ccc(F)cc1Cl)c1c(F)cc(F)cc1F |c:5,9|
SMILES:CCOC(=O)C1=C(C)NC(=N[C@H]1c1ccc(F)cc1Cl)c1c(F)cc(F)cc1F |c:5,9|

Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication was effectively inhibited by Z060228 in the supernatants of the HepG2.2.15 cells. Z060228 exhibited effects on the self-assembly of Cp149. SEC data revealed that Z060228 altered the equilibrium (a state of stability) of Cp149 assembly.

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