Name: BMS-279700
Rating: 5 (10 reviews)

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HIT ID:HIT212715143
Cas No:240814-54-4
常用名:BMS-279700
IUPAC:N-(2-chloro-6-methylphenyl)-12-[(3S)-3-methylpiperazin-1-yl]-2,4,8,13-tetraazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine
IUPAC:N-(2-chloro-6-methylphenyl)-12-[(3S)-3-methylpiperazin-1-yl]-2,4,8,13-tetraazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine
InChI key:PUNYTBZWCMNSRO-AWEZNQCLSA-N

分子式:C21H22ClN7
分子量:407.91
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:3.4832485
SMILES:C[C@H]1CN(CCN1)c1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2n1
SMILES:C[C@H]1CN(CCN1)c1ccc2nc(Nc3c(C)cccc3Cl)c3cncn3c2n1

BMS-279700 is a potent oral activity inhibitor that is part of a new family of aniline 5-azimidazolaquoxaline analogs and has excellent anti-inflammatory activity in vivo, as well as in vitro activity against p56LCK and T cell proliferation, blocking the production of pro-inflammatory cytokines (IL-2 and TNFα) in vivo.

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