Name: BMS-243117
Rating: 5 (10 reviews)

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HIT ID:HIT212715147
Cas No:225521-80-2
常用名:BMS-243117
别名:UNII-MBE6KWV0QI, MBE6KWV0QI, CHEMBL67237
别名:UNII-MBE6KWV0QI, MBE6KWV0QI, CHEMBL67237
IUPAC:2-[(tert-butylcarbamoyl)amino]-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide
IUPAC:2-[(tert-butylcarbamoyl)amino]-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide
InChI key:FIVXJBFMVDAATB-UHFFFAOYSA-N

分子式:C20H21ClN4O2S
分子量:416.92
氢键供体数 (HBD):3
氢键受体数 (HBA):3
LogP:5.1888733
SMILES:Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)NC(C)(C)C)sc2c1
SMILES:Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)NC(C)(C)C)sc2c1

BMS-243117 is an effective selective LCK inhibitor with good cell activity (IC(50)=1.1 microM) and inhibition of T cell proliferation, which has great potential for therapeutic immunosuppression and the treatment of diseases such as rheumatoid arthritis and asthma.

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